CoMalart Plus

Product Class – Over the Counter

Therapeutic Class – Antimalarial (Artemisinin Combination Therapy)

Active Ingredients – Artemether & Lumefantrine

Strength – Artemether 80mg & Lumefantrine 480mg

Indications – Treatment of Acute Uncomplicated Falciparum Malaria


Cautions – Electrolyte Disturbances, Concomitant use with other drugs known to cause QT-interval prolongation (ask your cardiologist); Monitor patients unable to take food (greater risk of recrudescence/recurrence); Avoid in Acute porphyria

Contra-indications – History of Arrhythmias, History of Clinically relevant Bradycardia and of Congestive heart failure accompanied by reduced left ventricular ejection fraction; Family history of sudden death or congenital QT interval prolongation (Ask your Cardiologist)

Hepatic (Liver) Impairment – Caution in Severe impairment

Renal (Kidney) Impairment – Caution in Severe impairment; monitor ECG and plasma potassium concentration

Pregnancy – Toxicity in animal studies with Artemether; Use only if potential benefits outweigh risk.

Breast-Feeding – Avoid breast feeding for at least 1 week after last dose; present in milk in animal studies.

Side Effects – Abdominal pain, Diarrhoea, Vomiting, Nausea, Anorexia; Palpitation, Prolonged QT Interval, Cough, Headache, dizziness, Sleep Disturbances, Asthenia, Paraesthesia, Arthalgia, Myalgia; Pruitus, Rash, Less commonly Ataxia, Hypoaesthesia, and Clonus


Weight Range (Kg) Total Tablets Dosage Regimen
Day 1 Day 2 Day 3
0hrs 8hrs 24hrs 36hrs 48hrs 60hrs
35 & above 6 1 1 1 1 1 1