Product Class – Over the Counter
Therapeutic Class – Antimalarial (Artemisinin Combination Therapy)
Active Ingredients – Artemether & Lumefantrine
Strength – Each 5ml spoonful after reconstitution contains Artemether 15mg & Lumefantrine 90mg
Indications – Treatment of Acute Uncomplicated Falciparum Malaria
Cautions – Electrolyte Disturbances, Concomitant use with other drugs known to cause QT-interval prolongation (ask your cardiologist); Monitor patients unable to take food (greater risk of recrudescence/recurrence); Avoid in Acute porphyria
Contra-indications – History of Arrhythmias, History of Clinically relevant Bradycardia and of Congestive heart failure accompanied by reduced left ventricular ejection fraction; Family history of sudden death or congenital QT interval prolongation (Ask your Cardiologist)
Hepatic (Liver) Impairment – Caution in Severe impairment
Renal (Kidney) Impairment – Caution in Severe impairment; monitor ECG and plasma potassium concentration
Pregnancy – Toxicity in animal studies with Artemether; Use only if potential benefits outweigh risk.
Breast-Feeding – Avoid breast feeding for at least 1 week after last dose; present in milk in animal studies.
Side Effects – Abdominal pain, Diarrhoea, Vomiting, Nausea, Anorexia; Palpitation, Prolonged QT Interval, Cough, Headache, dizziness, Sleep Disturbances, Asthenia, Paraesthesia, Arthalgia, Myalgia; Pruitus, Rash, Less commonly Ataxia, Hypoaesthesia, and Clonus
Dose:
FOR ORAL USE ONLY
HOW TO MIX: Slowly add freshly boiled and cooled water up to the mark on the bottle and shake vigorously to form a homogenous suspension. Adjust volume up to the mark by adding more water. This makes 60ml of suspension.
A full course therapy of three days is essential in order to avoid recrudescence. Vomiting within an hour requires repeating the dose.
It should be taken with FOOD.
| Body Weight(kg) | Number of Millilitres (ml) | ||
|---|---|---|---|
| Day 1 | Day 2 | Day 3 | |
| 5 | 7ml | 7ml | 7ml |
| 7.5 | 10ml | 10ml | 10ml |
| 10 | 14ml | 14ml | 14ml |
| 15 | 20ml | 20ml | 20ml |
